Using a new model of MND to test several potential new therapies.
Principal Investigator: Dr Mark Baker
Lead Institution: Newcastle University
MND Association Funding: £293,743
Funding dates: July 2023 - June 2026
About the project
There is increasing evidence to suggest that toxic proteins involved in the development and progression of MND (such as TDP-43) can spread from degenerating motor neurons to healthy nearby motor neurons, where they start to cause damage. Dr Mark Baker at the University of Newcastle has developed a novel model of MND where this spread of toxic proteins between neurons can be observed, and which closely reflects the disease processes seen in people with MND. This project aims to use this new model to test several therapeutic compounds which may block the toxic effects and spread of TDP-43 between neurons. The most promising of these compounds may be further developed and could be taken forward in clinical trials for people with MND.
What could this mean for MND research?
This project aims to find new potential therapies of MND using a new model of the disease. It is hoped the project will identify promising candidates which could then be tested further in clinical trials to see if they might be beneficial for people with MND.
Project code: 996-797
