Understanding more about the role that CCDC146 may play in motor neuron damage in MND.
PhD Student: Connie Treanor
Principal Investigator: Dr Johnathan Cooper-Knock
Lead Institution: University of Sheffield
MND Association Funding: £129,782
Funding dates: March 2025 - August 2028
About the project
All proteins have specific functions within cells, and a protein called CCDC146 has an important role in maintaining the shape and structure of cells. Previously, this research group identified a link between higher amounts of CCDC146 in people living with MND and a faster development of the disease. They gathered promising evidence that reducing the expression of CCDC146 in motor neurons grown in the lab helps to improve their health, however, it is not yet understood how this happens. The main aim of this project is to understand the function of CCDC146 in both healthy neurons and neurons developed from people with MND. This will allow the researchers to understand how reducing the amount of CCDC146 improves the health of MND motor neurons.
What could this mean for MND research?
This project will help to shed light on the potential of CCDC146 as a therapeutic target for MND. In order to determine the safety and effectiveness of targeting CCDC146 in MND, it is important to first understand the role of the protein in the body. Once the mechanisms are understood, it will help to inform the safety of this therapeutic approach. This will help to progress the research into testing in animal models and, ultimately, clinical trials.
Project code: 2409-792