Investigating the mechanisms which lead to damage of synapses using models of MND

Understanding more about the mechanisms that lead to synapse damage in MND.

PhD Student: TBC

Principal Investigator: Professor Gareth Miles

Lead Institution: University of St Andrews

MND Association Funding: £126,249

Funding dates: September 2024 - March 2028

About the project

Synapses are the connections between neurons and are vital in sending messages from one neuron to another and then to the muscles. In the early stages of MND these connection points are vulnerable and can become damaged. This results in the connections being lost and can lead to motor neuron death. One theory is that boosting the activity of cells which support motor neurons (astrocytes) may help to protect vulnerable synapses and reduce motor neuron death. This project will use 3D models, called organoids, to study the mechanisms that lead to damage to synapses and test methods of preserving the connections. These are models of MND which are developed from human skin cells and can replicate the brain and spinal cord.  

What could this mean for MND research?

This project aims to unravel the mechanisms behind synapse damage in MND. Once these mechanisms are understood the researchers can then look at ways to prevent this damage and reduce motor neuron death. This research could lead to the development of new potential treatments of MND. 

Project code: 2304-792