Furthering current understanding of the role of TMEM106B in faulty cell communication in MND and FTD.
PhD Student: TBC
Principal Investigator: Prof Kurt De Vos
Lead Institution: University of Sheffield
MND Association Funding: £129,782
Funding dates: October 2025 - March 2029
About the project
Neurones communicate through connections called synapses. In MND, the communication between neurones, and between neurones and muscles breaks down. Some people with MND also develop a type of dementia called frontotemporal dementia (FTD). TMEM106B is a gene which influences the chances of a person with MND also developing FTD. Initial work by the researchers suggests that TMEM106B is involved in bringing essential components to synapses to keep them functioning correctly. In this project, the researchers will aim to understand how TMEM106B works within the cell, and how it increases the risk of developing FTD. They hope to find new ways of restoring the communication between neurones in MND and FTD
What could this mean for MND research?
This project will increase understanding of the role of TMEM106B in MND and FTD. A better understanding of this could help to find new ways to restore communication between neurones, which could be a new target for treatments of both MND and FTD.
Project code: 2403-792
