Investigating the role that changes in the TBK1 gene may play in MND.
PhD Student: Sophie Shaw
Principal Investigator: Dr Sarah Langley
Lead Institution: Cardiff University
MND Association Funding: £130,087
Funding dates: October 2025 - March 2029
About the project
TANK-binding kinase 1 (TBK1) is a gene that has been associated with MND, but the reason for this is not known. One theory is that disruptions with TBK1 may lead to different versions of proteins being produced from the same gene. These proteins can cause damage in the cell. The researchers will investigate the impact that removing or changing TBK1 in motor neurones and microglia (which support motor neurones) has on protein production, and whether this is different between the different cell types. They will also look at the effect these changes have on the function of the cells.
What could this mean for MND research?
This project aims to further the current understanding of the role of TBK1 in MND. Having a better understanding of these processes could lead to the identification of new targets for treatments for MND.
Project code: 2434-792