Here you can find more information about the projects we are funding that are understanding clinical progression. Click on a project to find out more information and what the project means to a person living with MND.
Developing a detailed understanding of how the disease manifests and progresses in humans to ensure that fundamental laboratory research can be clearly linked to the ‘real world’ events occurring in people with MND.
Developing Motor Unit MRI as a diagnostic tool for MND
Prof Andrew Blamire/Dan Baxter-Beard
Neuroimaging and neurochemical biomarkers of brain ageing in MND
Dr James Cole/Ayodeji Ijishakin
Mapping patterns of TDP-43 protein clumps in the brain in MND
Dr Jenna Gregory
Using machine learning to find ALS and FTD sub-groups
Dr Ahmad Al Khleifat
Developing a home-based stimulation-free motor unit number estimate in MND
Dr James Bashford/Judith Bilgorai
Identification of non-coding RNA biomarkers for MND
Prof Majid Hafezparast
Developing remote monitoring tools for assessing disease progression in MND
Dr Emma Hodson-Tole/Nina Mitic
Classifying MND based on biochemical signatures
Dr David Lester
Investigating connectivity between the brain and muscle in MND
Dr Lara McManus
Characterising TDP-43 protein aggregates to identify biomarkers of MND
Dr Rebecca Saleeb
Profiling Immune Responses to Low-Dose IL-2 in MND
Prof Timothy Tree
Investigating the export of micoRNAs in extracellular vesicles in FUS MND and FTD
Professor Rob Layfield
Defining the relationship between lipids, statins and the risk of sporadic and familial MND
Dr Alexander Thompson