Exploring whether satellite cells could be a potential biomarker or treatment for MND.
Principal Investigator: Dr Giovanni Nardo
Lead Institution: Mario Negri Institute, Milan
MND Association Funding: £301,980
Funding dates: June 2025 - May 2028
About the project
Muscle wasting is commonly seen in MND. Satellite cells (SCs) are stem cells present in muscle, which help to replace damaged muscle fibres. This project will investigate the role of SCs in MND, and whether changes in SCs could be used as a biomarker to predict progression of disease. The researchers will also transplant new SCs into mouse models of MND to see if this can preserve muscles and prolong lifespan.
What could this mean for MND research?
This project is looking to identify a marker to help predict the progression of MND, as well as investigating whether replacing SCs could help to prevent muscle wastage. This could lead to the development of a potential new biomarker and treatment for MND.
Project code: 2384-791
